Telefoni: +86 21 6460 6569
itulau_fanua

oloa

Nicorandil（CAS# 65141-46-0) Ata Fa'aalia
  • Nicorandil（CAS# 65141-46-0) 1

Nicorandil（CAS# 65141-46-0)

Meatotino tau vailaau:

Fuafua mole C8H9N3O4
Molar Mass 211.17
Malosi 1.4271 (fa'atatau fa'atatau)
Lisi Lisi 92°C
Manu'a 350.85°C (fa'atatau fa'atatau)
Mata'imu 230°C
Solubility DMSO: >10 mg/mL. Solu i le methanol, ethanol, acetone po'o glacial acetic acid, soluble teisi i le chloroform po'o le vai, toetoe a le mafai ona solu i le eter po'o le benzene.
Ausa Malo 1.58E-08mmHg ile 25°C
Fa'aaliga Pa'epa'e i le pa'epa'e pei o le pauta tioata
Lanu pa'epa'e e pa'epa'e
Merck 14,6521
Tulaga Teuteu 2-8°C
Fa'asino Upu 1.7400 (fa'atatau)
MDL MFCD00186520
Meatotino Faaletino ma Vailaau Pa'epa'e tioata pa'epa'e, leai se manogi po'o sina manogi, oona. Solu i le methanol, ethanol, acetone po'o le acetic acid, soluble teisi i le chloroform po'o le vai, o nisi e le solo i le eter po'o le benzene. Liu liusuavai 88.5-93.5 °c. Mata'utia o'ona LD50 isumu (mg/kg):1200-1300 tautala, 800-1000 tui.
Fa'aoga Mo le puipuia o faʻamaʻi fatu fatu, angina pectoris
Su'esu'ega in vitro Nicorandil (100 mM) faʻateleina le faʻamaʻiina o le flavoprotein, ae e leʻi aʻafia ai le membrane o loʻo i ai nei, toe faʻafoʻisia laina mitoK (ATP) ma luga ole K (ATP) i faʻasalalauga maualuga atu nai lo le 10-fold. O le Nicorandil e faʻaitiitia le oti o le sela i se faʻataʻitaʻiga o le ischemic granulation, o se aʻafiaga o le cardioprotective lea e poloka e le mitoK(ATP) channel blocker 5-hydroxydecanoic acid ae le o le surfaceK(ATP). Aafiaga ole ala poloka HMR1098. Nicorandil (100 mM) taofia le leiloa o le TUNEL positivity, cytochrome C translocation, caspase-3 activation, ma mitochondrial membrane gafatia (Delta (Psi) (m)). Iloiloga o sela pisipisia i le fluorescence Delta(Psi)(m)-indicator, tetramethylrhodamine ethyl ester (TMRE) e le fluorescence activated cell sorter na faaalia ai, e taofia e nicorandil Delta(Psi)(m) depolarization i se tulaga-faalagolago (EC(50). ) e tusa ma le 40 mM, saturation 100 mM). I sela fa'aliliuina uma e lua, na fa'agaoioi ai e Nicorandil se fa'asa'o vaivai i totonu, glibenclamide-sensitive 80 pS K alalaupapa. I sela HEK293T, e sili ona fa'agaoioia e Nicorandil le alalaupapa K(ATP) o lo'o iai SUR2B. O Nicorandil (100 mM) na matua taofia le numera o sela i TUNEL-positive nuclei ma faʻateleina le 20 mM h2o2-induced caspase-3 gaioiga. O le faʻaogaina o le Nicorandil e faʻalagolago e puipuia ai le leiloa o le DeltaPsim faʻaosoina e le H2O2.
Suʻesuʻe i vivo Nicorandil (2.5 mg / kg i aso taʻitasi, po) faʻatasi ma Amlodipine (5.0 mg / kg i aso taʻitasi, po) tolu aso o gaioiga na matua puipuia ai suiga ma toe faʻaleleia le gaioiga o le enzyme i le maualuga e latalata i mea masani o isumu.

Fa'amatalaga Oloa

Faailoga o oloa

Fa'ailoga Mata'utia Xn – Fa'aleagaina
Tulaga lamatia R22 – E afaina pe a foloina
R41 – Tulaga lamatia o le faaleagaina mata
Fa'amatalaga Saogalemu S26 – Pe a pa'i i mata, fufulu vave i le tele o vai ma saili fautuaga fa'afoma'i.
S39 – Fai le puipuiga o mata/mata.
WGK Siamani 3
RTECS US4667600
HS Code 29333990
Oona LD50 i isumu (mg/kg): 1200-1300 tautala; 800-1000 iv (Nagano)

 

Folasaga

Nicolandil, e lauiloa foi o nicorandil amine, o se faʻalapotopotoga faʻapitoa. O loʻo taua i lalo se faʻamatalaga i meatotino, faʻaoga, sauniuniga ma faʻamatalaga saogalemu o nicorandil:

 

Tulaga lelei:

- O le Nicorandil o se ma'a tioata e leai ni lanu e mafai ona solu i vai ma so'o so'o.

- Ose vaila'au alkaline e mafai ona fa'agaioi ma acids e maua mai ai fa'atasiga masima.

- O Nicorandil e mautu i le ea, ae e mafai ona pala pe a faʻaalia i le maualuga o le vevela.

 

Fa'aaogā:

- Nicolandil e mafai foi ona faʻaaogaina i le faʻapipiʻiina o mea faʻapipiʻi faʻasolosolo, photosensitizers, ma isi.

 

Metotia:

- Nicolandil e masani ona saunia e ala i le tali atu o dimethylamine ma 2-carbonyl compounds.

- O le tali e faia i lalo o tulaga alkaline ma o le faʻavevela faʻafefe o loʻo faia i totonu o se solvent talafeagai.

 

Fa'amatalaga Saogalemu:

- Nicorandil e saogalemu mo tagata i lalo o tulaga lautele.

- Ae ui i lea, e tatau ona faʻaeteete ina ia aloese mai le faʻafesoʻotaʻi saʻo ma mata, paʻu, ma le manava.

- Fa'aaoga mea e puipui ai le tagata lava ia (PPE) e pei o matatioata saogalemu, totigilima ma mea faigaluega manava.

- Pe a faʻaaoga pe teuina nicorandil, e tatau ona faʻaeteete e aloese mai le faʻamumu ma tulaga maualuga o le vevela.

 

  • Muamua:
  • Sosoo ai:
    • Tusi lau savali iinei ma lafo mai ia i matou

    oloa fa'atatau