N(alpha)-fmoc-N(epsilon)-(2-chloro-Z)-L-lysine(CAS# 133970-31-7)

Fmoc-(2-chlorobenzyloxycarbonyl) lysine ose amino acid e masani ona fa'aaogaina ma mea nei:1. Fa'aaliga: pa'epa'e tioata pa'epa'e;
2. fua mole: C26H24ClNO5;
3. Molecular mamafa: 459.92g/mol;
4. Solubility: Soluble i solu faʻaletino e pei o le dimethyl sulfoxide (DMSO), dimethyl formamide (DMF), dichloromethane, ma isi, e le mafai ona solu i le vai;
5. Melting point: e uiga i le 170-175 ° C. O le faʻaaogaina muamua o le Fmoc-(2-chlorobenzyloxycarbonyl) lysine o se vaega puipuia ma faʻagaoioia i le faʻaogaina o polypeptides. O lona vaega carboxyl e mafai ona faʻagaoioia e fai ai se ester, ona oʻo lea i se faʻafefete faʻatasi ma se amino acid toega e faʻapipiʻi ai se filifili polypeptide. O le vaega Fmoc e mafai ona faigofie ona aveese pe a maeʻa le tali e faʻaalia ai le vaega amino puipuia.

O le auala e saunia ai le Fmoc-(2-chlorobenzyloxycarbonyl) lysine e masani ona aofia ai laasaga nei:

1. tali lysine fa'atasi ma le N-hydroxybutyrimide (Pbf) e fa'aofia ai se vaega puipuia;
2. lysine-Pbf fa'atupu fa'atasi ma le 2-chlorobenzyl alcohol e fai ai le Fmoc-(2-chlorobenzyloxycarbonyl) lysine;
3. O le oloa e maua mai i se solvent talafeagai ma faʻamamaina e ala i tioata e maua ai le oloa mama.

E tusa ai ma faʻamatalaga saogalemu, Fmoc-(2-chlorobenzyloxycarbonyl) lysine o se vailaʻau vailaʻau ma e tatau ona faia ni faiga saogalemu talafeagai. O mea faigaluega puipui talafeagai, e pei o totigilima a le falesuesue, matatioata, ma lavalava falesuesue, e tatau ona ofuina i le taimi o le suʻega. Aloese mai le manavaina o pauta po'o vaifofo, aloese mai le pa'i i le pa'u ma mata. A iai se fa'alavelave fa'afuase'i, fufulu vave i le tele o vai ma saili fesoasoani fa'afoma'i. Ia mautinoa o loʻo faʻaaogaina i totonu o se siosiomaga saogalemu falesuesue ma teuina lelei e puipuia ai faʻalavelave faʻafuaseʻi.