Methyl 2-cyanoisonicotinate（CAS# 94413-64-6)
Tulaga lamatia ma le Saogalemu
| Vasega o Tulaga Lamatia | 6.1 |
Auala gaosiga
o le faʻapipiʻi sini na saunia e ala i le faʻamaʻiina, amidation ma le faʻamama ma le methyl 2-methyl 4-pyridinecarboxylate (2) e fai ma mea amata. o lona fausaga na faʻamaonia e le 1H NMR ma le MS, ma o le aofaʻi o fua e 53.0%. O aʻafiaga o le fafagaina o fua, vevela tioata, taimi faʻaalia ma isi mea i luga o le oloa na suʻesuʻeina e suʻesuʻega faʻapitoa e tasi, ma o tulaga faʻagasologa na sili ona lelei: n (2): n (potassium permanganate) = 1.0: 2.5, crystallization temperature 0 ~ 5 ℃;n (methyl 2-carboxyl -4-pyridinecarboxylate):n (sulfoxide) = 1.0: 1.4, tali; o le faʻamaʻi faʻamaʻi e filifilia le trifluoroacetic anhydride-triethylamine system e fai ma sui faʻamaʻi. O le faagasologa e faigofie e faʻatino, o tulaga tali e agamalu, faigofie ona faʻateleina le gaosiga, ma e lelei lona aoga aoga.
Fa'aoga
Tobisostat e faʻaaogaina e togafitia ai le hyperuricemia tumau o le gout. Pe a faatusatusa i fualaau faasaina allopurinol (purine analog), o le a le afaina ai le purine ma le pyridine metabolism ma le enzyme, ma faʻaitiitia ai le uric acid O le aʻafiaga e sili atu le malosi, e le manaʻomia se faʻatonuga tele, ma sili atu le saogalemu. Methyl 2-cyano-4-pyridine carboxylate o se mea taua tele mo le faʻapipiʻiina o Tobiso.
