Methoxymethyl triphenylphosphonium chloride (CAS # 4009-98-7)

Fa'aoga

(Methoxymethyl) triphenylphosphorus chloride o loʻo faʻaaogaina e faʻapipiʻi ai le cefaltacin, o se vailaʻau faʻamaʻi ma anti-tumour. E faʻaaogaina foi e faʻapipiʻi ai se vaega o paclitaxel.

Sauniuniga

O se metotia mo le synthesizing (methoxymethyl) triphenylphosphorus chloride, e aofia ai laasaga nei: i lalo o le puipuiga o le nitrogen, faʻaopoopo le 50mL o le anhydrous acetone i totonu o se reactor, ona faʻaopoopoina lea o le 32g o le triphenylphosphine, faʻaosoina ma siitia le vevela i le 37 ° C, faʻaauau pea le vevela. , faaopoopo le 20g o le methyl chloromethyl ether i le reactor, ona sosoo ai lea tali i le 37 ° C mo le 3h, fa'agesegese le vevela i le 47 ° C i le fua o le 1 ° C / min, o le tali na faʻaauau mo le 3h, na taofia le tali, ma le 37.0g (methoxymethyl) triphenylphosphorus chloride na maua i le filtration. , anhydric eter fufuluina ma faʻamago ma se fua o le 88.5%.