Ethyl 1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo[3 4-c]pyridine-3-carboxylate（CAS# 503615-07-4 )

Folasaga

O loʻo taua i lalo se faʻamatalaga i meatotino, faʻaoga, metotia sauniuni ma faʻamatalaga saogalemu o le apixaban intermediate 3:

Tulaga lelei:

Apixaban intermediate 3 o se faʻalapotopotoga faʻapitoa. E mausali ma soluble i solvents organic pei ole ether ma ethyl acetate.

Fa'aaogāina: E masani ona fa'aoga mo fa'ama'i fa'ama'i tipiga ma togafitiga o tiga tuga.

Metotia:

O le auala sauniuni o le apixaban intermediate 3 e mafai ona faʻatinoina i laasaga nei: p-nitrobenzoic acid e faʻaalia ma le hypobutylthiourea i le faʻatasi o le acetic acid ma le thionyl chloride e maua ai le N-(p-nitrophenyl) -N-(hypobutylthioylurea) formic acid, ona tali atu lea i le sodium hydroxide i le sodium oxide ma le methanol solution e maua ai le apixaban. vaeluagalemu 3.

Fa'amatalaga Saogalemu: E mana'omia ona mulimulita'i faiga fa'agaioiga mo le saogalemu pe a fa'aogaina ma fa'aogaina lenei fa'aputuga. Fa'afeso'ota'i sa'o po'o le manava e mafai ona afaina tele ai le soifua maloloina o tagata. O ana fa'amatalaga fa'apitoa mo le saogalemu e tatau ona iloiloina ma fa'agasolo e tusa ai ma tulafono fa'atatau ma ta'iala e fa'amautinoa ai le fa'aoga saogalemu ma le fa'aogaina. Pe a faia ni su'esu'ega fa'akomepiuta, e tatau ona fa'agaioia i lalo ole tulaga su'esu'e talafeagai ma mea e puipui ai le tagata lava ia e pei o matatioata vaila'au, totigilima puipui, ma lavalava puipui e tatau ona fa'aoga.