Boc-L-aspartic acid 1-benzyl ester（CAS# 30925-18-9)

Folasaga

Boc-Asp-OBzl(Boc-Asp-OBzl) ose fa'atasiga e iai mea nei:

1. Fa'aaliga: Pa'epa'e tioata malō.

2. Fuafuaga mole: C24H27N3O7.

3. Molecular mamafa: 469.49g/mol.

4. Liu liusuavai: tusa o le 130-134 ° C.

Boc-Asp-OBzl o loʻo faʻaaogaina lautele i le biochemistry ma synthetic organic chemistry, e masani ona faʻaaogaina i le faʻaogaina o peptides, proteins ma vailaʻau, faʻatasi ai ma faʻaoga nei:

1. Peptide synthesis: I le avea ai o se vaega o le vaega puipuia (Boc protecting group), o le vaega amino i le aspartic acid amino acid e mafai ona puipuia.

2. Suʻesuʻega vailaʻau: mo le tuʻufaʻatasia o vailaʻau peptide faʻatasi ai ma le faʻamaʻi, faʻamaʻi-tumor ma le faʻatonuga o le puipuiga.

3. Enzyme tali: Boc-Asp-OBzl e mafai ona faaaogaina mo enzyme catalyzed tali substrate.

Ole auala ole saunia ole Boc-Asp-OBzl e faʻapea:

O le aspartic acid ma le benzoyl chloride o loʻo faʻamalosia e fausia ai le tert-butoxycarbonyl-aspartic acid benzyl ester (Boc-Asp-OMe), lea e mulimuli ane faʻafeiloaʻi ma le sodium hexoxide e maua ai se vaeluaga ile foliga ole N-hexanoate. Mulimuli ane, e maua ai se tali benzoylation e maua ai Boc-Asp-OBzl.

Faʻalogo lelei i faʻamatalaga saogalemu nei pe a faʻaaogaina le Boc-Asp-OBzl:

1. O le fa'afefiloi e mafai ona mafua ai le ita ma fa'afefe i le tino o le tagata, ma e tatau ona 'alofia le fa'afeso'ota'i sa'o ma le pa'u ma mata.

2. E tatau ona faia ni puipuiga talafeagai i le taimi o le taotoga, e pei o le ofuina o totigilima ma mata tioata.

3. Fa'amamago ma fa'amaufa'ailoga i le taimi e teu ai, ma 'alo 'ese mai le afi ma le fa'ama'i.

4. A faʻaaoga ma faʻaaogaina Boc-Asp-OBzl, faʻamolemole mulimuli i le faʻaogaina saʻo o le falesuesue ma le saogalemu.

Faamolemole ia matau pe a faʻaaogaina Boc-Asp-OBzl poʻo soʻo se vailaʻau, e tatau ona e mulimulitaʻi i taʻiala o le saogalemu, ma faia le puipuiga o le tagata lava ia ma suʻesuʻega lamatia e tusa ai ma le tulaga moni.