5-Fluorocytosine（CAS# 2022-85-7)
Tulaga lamatia ma le Saogalemu
| Tulaga lamatia | R40 – Fa'amaoniga fa'atapula'a o se a'afiaga tuga R36/37/38 – Fa'aitaita'i i mata, faiga manava ma le pa'u. R63 – Fa'alavelave e ono afaina ai le pepe e le'i fanau mai |
| Fa'amatalaga Saogalemu | S22 – Aua le manava pefu. S24/25 – Aloese mai le fa'afeso'ota'i ma pa'u ma mata. S45 – I se fa'alavelave po'o ua e lagona le le lelei, saili vave fautuaga fa'afoma'i (fa'aali le igoa pe a mafai.) S36/37 – Fai ofu puipui ma totigilima talafeagai. S36/37/39 – Fai ofu puipui talafeagai, totigilima ma mata/mata. S27 – Aveese loa lavalava uma ua afaina. S26 – Pe a pa'i i mata, fufulu vave i le tele o vai ma saili fautuaga fa'afoma'i. |
| WGK Siamani | 2 |
| RTECS | HA6040000 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29335990 |
| Mata'utia Fa'amatalaga | Oona/Malamalama |
| Vasega o Tulaga Lamatia | AGA, SENSE MALAMA |
| Oona | LD50 i isumu (mg/kg): >2000 tautala ma sc; 1190 ip; 500 iv (Grunberg, 1963) |
5-Fluorocytosine（CAS# 2022-85-7) Folasaga
uiga lelei
O lenei oloa o se pa'epa'e pa'epa'e pe pa'epa'e pa'epa'e tioata, e leai se manogi po'o sina manogi. Soluble teisi i le vai, solubility o le 1.2% i le 20 °C i le vai, soluble teisi i le ethanol; E toetoe lava a le mafai ona solu i le chloroform ma le eter; Solu i totonu o le vai faʻafefete hydrochloric acid poʻo le faʻafefeteina o le sodium hydroxide solution. E mautu i le vevela o le potu, fa'afefe tioata pe a malulu, ma se vaega itiiti e liua i le 5-fluorouracil pe a vevela.
O lenei oloa o se vailaʻau faʻamaʻi faʻamaʻi faʻapipiʻiina i le 1957 ma faʻaaogaina i le falemaʻi i le 1969, faʻatasi ai ma aʻafiaga faʻamaʻi faʻamaʻi i Candida, cryptococcus, lanu vali ma Aspergillus, ma e leai se aafiaga faʻalavelave i isi gaʻo.
O lona faʻalavelave faʻalavelave i gaʻo e mafua ona o lona ulufale atu i totonu o sela o gaʻo maʻaleʻale, lea i lalo o le gaioiga a le nucleopyine deaminase, aveese vaega amino e fausia ai le antimetabolite-5-fluorouracil. O le mea mulimuli ua liua i le 5-fluorouracil deoxynucleoside ma faʻalavelaveina le thymine nucleoside synthetase, poloka le liua o le uracil deoxynucleoside i le thymine nucleoside, ma afaina ai le DNA synthesis.
fa'aoga
Antifungals. E masani ona faʻaaogaina mo le mucocutaneous candidiasis, candidal endocarditis, candidal arthritis, cryptococcal meningitis ma chromomycosis.
Fa'aoga ma fua ole tautala, 4~6g i le aso, vaevaeina i le 4 taimi.
saogalemu
E tatau ona siaki i taimi uma le aofa'i o le toto i le taimi o le fa'atonuga. O tagata mama'i e le lava le ate ma fatuga'o ma fa'ama'i toto ma fafine ma'itaga e tatau ona fa'aaoga ma le fa'aeteete; Contraindicated i tagata mamaʻi e ogaoga le le atoatoa o le fatu.
Paolo, teuina malu.
