5-Bromo-3-nitro-2-pyridinol（CAS# 15862-34-7)
Tulaga lamatia ma le Saogalemu
| Tulaga lamatia | R22 – E afaina pe a foloina R37/38 – Fa'aitaita i le manava ma le pa'u. R41 – Tulaga lamatia o le faaleagaina mata R36/37/38 – Fa'aitaita'i i mata, faiga manava ma le pa'u. R20 – E afaina pe a manava |
| Fa'amatalaga Saogalemu | S26 – Pe a pa'i i mata, fufulu vave i le tele o vai ma saili fautuaga fa'afoma'i. S36/37/39 – Fai ofu puipui talafeagai, totigilima ma mata/mata. S36 – Fai ofu puipui talafeagai. |
| UN ID | 2811 |
| WGK Siamani | 3 |
| HS Code | 29337900 |
| Mata'utia Fa'amatalaga | Fa'aleagaina |
| Vasega o Tulaga Lamatia | FAAFITAU |
Faʻamatalaga Faʻamatalaga
| Fa'aoga | 5-bromo-2-hydroxy-3-nitropyridine o se vailaʻau faʻale-aganuʻu e mafai ona faʻaaogaina e saunia ai mea faʻapipiʻi 3-amino-1-(2-oxo-2-(3 '-(trifluoromethyl)-[1,1'-biphenyl) ]-4-yl) ethyl)-5-(pyrrole alkyl-1-yl-sulfonyl) pyridin-2 (1H) -one, o lenei tuufaatasiga o se DOCK1 inhibitory compound. |
| auala fa'aopoopo | nitric acid (60-61%,3.5mL) sa faaopoopo i le vaifofo (10mL) o le 5-bromopyridine -2(1H)-tasi (1.75g,10.1mmol) i le sulfuric acid i le 0 ℃. O le faʻafefiloi e faʻatagaina e faʻamafanafana i le vevela o le potu ma faʻafefe mo le 3 itula. E sasaa le paluga tali i totonu o le vai aisa ma o le mea e maua mai ai e faʻaputuina e ala i le faʻamamaina. O le mea na maua na fufuluina i le vai ma faʻagogo i le vacuum, ma tuʻuina atu le 5-bromo-2-hydroxy-3-nitropyridine (960mg,43% fua) e pei o se paʻepaʻe paʻepaʻe. 1H NMR(500MHz,CDCl3)δ:8.57(s,1H),8.26(s,1H). |
Tusi lau savali iinei ma lafo mai ia i matou
