4-Bromo-3-fluorobenzoic acid (CAS # 153556-42-4)
Faʻamatalaga Faʻamatalaga
| Fa'aoga | 4-bromo-3-fluorobenzoic acid o se vailaʻau mataʻutia taua e mafai ona faʻaaogaina e saunia ai vailaʻau eseese (e pei o le vailaʻau faʻamaʻi kanesa benzamit). |
| Metotia fa'atasi | 4-bromo-3-fluorobenzoic acid e mafai ona maua i le faʻamaʻiina o le 4-bromo-3-fluorotoluene e ala i le potassium permanganate. (1) faʻamaʻiina: 100kg o kg4-bromo -3-fluorotoluene, 120kg vai ma 0.1kg o gaʻo ava polyether sodium sulfate (AES) o loʻo faʻaopoopoina faʻasolosolo i le K-400L tioata faʻafefe tali (fausia e Jiangsu fale gaosi oloa vailaʻau. meafaigaluega co., ltd.) faʻatasi ma faʻamalosi ma faʻamafanafana ma condensation reflux masini, ona 167kg o le potassium permanganate o loʻo faʻaopoopo lemu i lalo o le faʻafefeteina tulaga, tausia i totonu o se tulaga faʻafefete, ma tali atu mo le 9 itula, taofi le tali pe a uma le reflux solution e le o toe iai ni pulu suauʻu; (2) Filtration: faamama le tali tali maua i le laasaga (1) a'o vevela e maua ai le filtrate o loʻo i ai le oloa faʻatatau 4-bromo -3-fluorobenzoic acid; (3) Aveese le potassium permanganate: Ina ia mafai ona aveese le potassium permanganate o totoe i totonu o le filtrate, e tatau ona faaopoopo le 0.1kg o le sodium sulfite i le filtrate maua i le laasaga (2), o le aofaiga faaopoopo o le sodium sulfite e faavae i luga o le vai manino ma le lanu viole o le fofo. (4) acidification: i le tulaga faʻavevesi, faʻaopoopo lemu le vailaʻau i le vaifofo maua i le laasaga (3) faʻatasi ai ma le faʻaogaina o le 12mol / L faʻamalosi hydrochloric acid. pe a oʻo i le pH o le vaifofo e 2.2, taofi le faʻapipiʻiina o le hydrochloric acid faʻapitoa ma faʻaauau le tali mo le 30min. (5) tioata: i le tulaga faʻafefeteina, o le vaifofo na maua i le laasaga (4) e faʻamafanafanaina i le 2 ° C, ma o tioata faʻapipiʻi i le fofo o le 4-bromo-3-fluorobenzoic acid. I le taimi o le taʻaloga, e tatau ona faʻaosoina pea, a leai o le 4-bromo-3-fluorobenzoic acid o le a fausia ai se malosi tele, lea e faigata ona taulimaina i isi gaioiga; (6) Filtration ma fufuluina: O le vai fefiloi o loʻo i ai tioata 4-bromo-3-fluorobenzoic acid na maua i le laasaga (5) e centrifuged ina ia maua ai se keke faʻamama o se oloa faʻamaʻi 4-bromo-3-fluorobenzoic acid, o le oloa mama. e fufuluina i le vai mama ma fa'a'ese'ese (fa'aaogaina o le centrifuge ma le galuega fufulu) e maua ai le 4-bromo-3-fluorobenzoic acid mama; (7) Faʻagogo: O le 4-bromo-3-fluorobenzoic acid solid ua saunia i le laasaga (6) e faʻamago i le 75 ° C mo le 12 itula e maua ai le 197 kg4-bromo-3-fluorobenzoic acid, o loʻo i totonu e sili atu nai lo le 98. %. |
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