2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine(CAS#865363-93-5)
Fa'ailoa 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5), o se analog nucleoside suatia eleele ua setiina e faʻafouina le matata o le biology mole mole ma suʻesuʻega vailaʻau. O lenei tuufaatasiga fou ua mamanuina e faʻaleleia atili ai le malamalama o fesoʻotaʻiga nucleic acid ma gaioiga feaveaʻi, ma avea ai ma meafaigaluega taua mo tagata suʻesuʻe ma saienitisi tutusa.
2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine o loʻo faʻaalia i ona suiga faʻapitoa faʻapitoa, lea e aofia ai le ethynyl ma le fluorine suitulaga i le 4' ma le 2' tulaga, i le faasologa. O nei suiga e le gata ina fa'aleleia ai le mautu ma le bioavailability ae fa'apena fo'i ona fa'atupuina lona agava'a e tu'i i totonu o sela feavea'i, e mafai ai ona sili atu le lelei o le tu'uina atu ma le fa'aogaina i totonu o faiga fa'aola eseese.
O lenei nucleoside analog ua faʻaalia le faʻamoemoega gafatia i faʻaoga eseese, e aofia ai suʻesuʻega antiviral ma antikancer. O lona gafatia e fa'ata'ita'i ai nucleosides fa'anatura a'o fa'aalia uiga fa'apitoa o meaola fa'aola e avea ai ma sui fa'apitoa mo le atina'eina o ni vaila'au fa'afoma'i fou. E mafai e tagata suʻesuʻe ona faʻaogaina le 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine e suʻesuʻe ai le RNA ma le DNA synthesis, suʻesuʻe faʻafesoʻotaʻi enzyme, ma suʻesuʻe auala o gaioiga o vailaʻau o loʻo iai.
I le faaopoopo atu i ana suʻesuʻega talosaga, o lenei tuufaatasiga o loʻo sauni foi e faia se sao taua i le atinaʻeina o togafitiga o le isi augatupulaga. E ala i le tuʻuina atu o faʻamatalaga i le amio nucleic acid ma fegalegaleaiga, 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine e mafai ona fesoasoani i le mamanu o togafitiga sili atu ona lelei ma faʻatatau mo faʻamaʻi eseese.
I se aotelega, 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5) o se analog nucleoside pito sili ona lelei e ofoina atu avanoa le mafaatusalia mo suʻesuʻega ma atinaʻe i le molecular biology ma pharmacology. Talia le lumanaʻi o suʻesuʻega faʻasaienisi ma lenei faʻapitoa faʻapitoa ma tatala avanoa fou i au sailiga suʻesuʻega.
