2-Chloro-3-fluoro-6-picoline（CAS# 374633-32-6)

Folasaga

Faʻaaliga: E masani ona leai se lanu i le moli samasama vai, o nei foliga vaaia e faʻaalia ai atonu e maaleale i le malamalama ma le vevela, ma e tatau ona faia ni faiga e aloese ai mai le malamalama ma le vevela i le taimi o le teuina ma le felauaiga, e pei o le faʻaaogaina o fagu tioata lanu enaena ma le teuina. i totonu o se faleteuoloa malulu e puipuia ai le faʻalauteleina o lanu ma faʻaleagaina.

Solubility: O le tuufaatasiga e lelei solubility i solutions masani masani, e pei o le toluene ma le dichloromethane, mulimuli i le mataupu faavae o solubility tutusa, ma e i ai se sootaga ma solvents organic ona o le vaega hydrophobic o le mole; Ae ui i lea, o le solubility i le vai e maualalo, ma o le malosi o le hydrogen fusia i le va o mole mole vai e faigata ona talepeina lelei e le mole, ma faigata ai ona faʻasalalau.
Fa'apuna ma le mamafa: O fa'amaumauga o le fa'apuna e feso'ota'i vavalalata ma lona fe'avea'i ma e mafai ona tu'uina atu ai ta'iala autu mo fa'agaioiga e pei o le fa'amama ma le fa'amamāina, ae paga lea e le'i fa'ailoaina lautele le tau fa'apuna fa'apitoa. O lona mamafa e sili atu teisi atu nai lo le vai, ma o le malamalama i le mamafa e mafai ona fesoasoani e faʻatusatusa saʻo le fesoʻotaʻiga o le voluma ma le tele o suiga i faʻataʻitaʻiga faʻataʻitaʻiga poʻo faiga faʻapisinisi e pei o le fesiitaiga o le suavai ma le mita saʻo.
O mea tau vailaau
Suiga fa'afoliga: O le chlorine atom ma le fluorine atom i le mole o nofoaga ia e mafai ona gaoioi. I le nucleophilic substitution reaction, malosi nucleophiles e mafai ona osofaʻia nofoaga o loʻo i ai chlorine ma fluorine atoms, sui ia atoms tutusa, ma faʻatupuina fou pyridine derivatives. Mo se faʻataʻitaʻiga, ua tuʻufaʻatasia ma nisi nucleophiles o loʻo i ai le nitrogen ma le sulfur e atiaʻe ai se faʻasologa o vailaʻau heterocyclic o loʻo i ai le nitrogen ma fausaga sili atu ona lavelave mo le suʻeina o vailaʻau poʻo le faʻapipiʻiina o mea.
Redox tali: o le pyridine mama lava ia e matua mautu, ae pe a faʻapipiʻi faʻamaʻi malosi, e pei o le potassium permanganate ma le hydrogen peroxide ma tulaga faʻamaʻi, e mafai ona tupu le faʻamaʻiina, e mafua ai le faʻaleagaina poʻo le suiga o le fausaga o le mama pyridine; Fa'afeagai, fa'atasi ai ma se sui fa'aitiitiga talafeagai, e pei o u'amea hydride, e fa'apea e mafai ona fa'a'ele'elea fa'amauina fa'amauina fa'atasi.
Lona fa, o le synthesis method
O le auala fa'apipi'i masani o le amata mai i mea faigofie pyridine ma fa'agasolo malie le fa'atulagaina o le fa'atulagaina e ala i tali halogenation ma fluorination. O mea amata pyridine compounds e muamua filifilia methylated ma faʻafeiloaʻi vaega methyl i le taimi e tasi; Ona faʻaaoga lea o mea faʻafefe halogenation, e pei o le chlorine ma le chlorine vai, faʻatasi ai ma catalysts talafeagai ma tulaga tali, e ausia ai le faʻaofiina o atoms chlorine; Mulimuli ane, o mea faʻapipiʻi faʻafefe, e pei o Selectfluor, na faʻaaogaina e faʻamaonia saʻo ai le nofoaga autu e maua ai le 2-chloro-3-fluoro-6-methylpyridine.
Fa'aoga
O vailaʻau faʻapipiʻi vaʻaia: o lona fausaga tulaga ese e alofagia e fomaʻi vailaʻau, ma o se tulaga maualuga maualuga mo le atinaʻeina o vailaʻau fou antibacterial, antiviral, ma antitumor. O mea fa'aeletoroni ma le fa'afanua o le pyridine mama ma a latou mea e suitulaga e mafai ona fa'apipi'i fa'apitoa i polotini fa'amoemoe i vivo, ma e fa'amoemoe e fa'aliliuina e avea ma mea fa'agaioiga ma sili ona lelei pe a mae'a suiga fa'asolosolo.
Fa'asaienisi mea: I totonu o le fanua o mea fa'apipi'i mea fa'aola, e mafai ona fa'aaogaina e gaosia ai mea polymer galue, mea fa'alelei, ma isi mea, e ala i lona mafaia ona fa'ailoa sa'o le chlorine, fluorine atoms ma pyridine structures, fa'ameamea fa'ameamea fa'atasi ma le eletise fa'apitoa ma le mata. meatotino, ma faʻalauteleina le atinaʻeina o tekonolosi faʻaonaponei e pei o mea atamai ma mea faʻaalia.