2 4-Difluorobenzoic acid（CAS# 1583-58-0)

Fa'atatauga

2, 4-difluorobenzoic acid o se vailaʻau taua ma vailaau faʻamaʻi, e pei ole 2, 4-difluorobenzoic acid e masani ona faʻaaogaina e faʻapipiʻi ai vailaʻau faʻamaʻi fluconazole, voriconazole ma vailaʻau vailaʻau vavalo 4-fluorosalicylic acid, vailaʻau vavalo 3, 5-difluoroaniline, ma isi. . 2, 4-difluorobenzoic acid e mafai foi ona faʻaaogaina i tioata vai meafaitino, o loʻo i ai le lelei o le maualuga o le tau ma faʻamoemoe lelei maketi.

Sauniuniga

Faʻaopoopo le 2, 4-dinitrotoluene ma le vai i le vaʻa tali, fetuunai le tau o le pH i le 7, faʻafefe ma vevela i le 75 ° C. O le potassium permanganate, le magnesium sulfate ma le faʻasologa o vaega na faʻaopoopoina i vaega. A maeʻa ona faʻaopoopo, faʻaauau pea ona faʻafefe ma tali i le vevela tumau mo le 3 itula. Fa'amama a'o vevela ma fufulu le keke faamama ile vai vevela. Faʻatasi le filtrate, faʻafefeteina ma le 35% hydrochloric acid i le pH 2-3, o loʻo i ai se numera tele o paʻepaʻe paʻepaʻe pe a maeʻa tioata atoa, faʻamamaina, fufuluina, toe faʻamalo, ma faʻagogo e maua ai tioata paʻepaʻe e pei o le 2,4-dinitrobenzoic acid . Ole fua ole 2, 4-dinitrotoluene ile potassium permanganate ole 2.4:1. O le gaosiga o oloa o lenei laasaga e 90.7%.

faʻaopoopo N, N-dimethylmethylphthalamide i totonu o le pusa tali, vevela i le 100 ~ 110 ℃, faʻamafanafana mo le 0.5 ~ 1h. Fa'aopopo mago anhydrous potassium fluoride i lalo o le fa'aosoina ma fa'atumauina le vevela mo le 0.5-1h. A maeʻa lena, 2, 4-dinitrobenzoic acid ma le hexyltrimethylammonium bromide na vave faʻaopoopo i le vaʻa tali i le taimi e tasi, ma faʻaauau le faʻamafanafanaina i le 120 ℃, tumau le vevela ma faʻaauau pea le faʻafefe. A maeʻa le 7h o le reflux reaction, e toe maua mai le solvent e ala i le faʻamama, ona faʻafefe ai lea o le vai faʻafefe i le ausa. O le vaega na aoina o se emulsion paepae. A maeʻa ona tu mo se vaitaimi, o le vaega o le suauʻu sini e goto ifo i le pito i lalo, o le vai manino paʻepaʻe i luga o le pito i luga e sasaa, ma faʻamafanafana le suauu e faʻafefe ai tioata paʻepaʻe e maua ai se mea leaga; o le oloa mama ua recrystallized, Suction filtration, fufuluina, ma faʻamago e maua ai tioata paʻepaʻe o le 2,4-difluorobenzoic acid. Ole fua ole aofa'i ole 2,4-dinitrobenzoic acid ile potassium fluoride ole 2.7:1. O le gaosiga o oloa o lenei laasaga e 72.4%.

Folasaga
2,4-Difluorobenzoic acid o se faʻalapotopotoga faʻapitoa. O loʻo taua i lalo se faʻamatalaga i meatotino, faʻaoga, metotia sauniuni ma faʻamatalaga saogalemu o le 2,4-difluorobenzoic acid:

Tulaga lelei:
- Faʻaaliga: 2,4-Difluorobenzoic acid o se tioata paʻepaʻe paʻepaʻe.
- Solubility: E solu i solu masani masani e pei ole ethanol, methanol ma methylene chloride.

Fa'aaogā:
- Mea faʻapitoa: E mafai foʻi ona faʻaaogaina e avea o se tasi o mea mataʻutia mo le saunia o mea faʻapitoa ma ata tifaga.
- Fa'aaogāga fa'apisinisi: 2,4-difluorobenzoic acid e mafai ona fa'aogaina i le fa'aeletonika fa'aeletonika, fa'alavalava ma palasitika pisinisi fa'atasi ai ma a'afiaga a'afia, fa'ama'i fa'ama'i ma a'afiaga a'afia.

Metotia:
- 2,4-Difluorobenzoic acid e mafai ona maua i le fluorination o le hydrofluoric acid ma le p-methylanisole.

Fa'amatalaga Saogalemu:
- Pe a fa'agaioi, e tatau ona 'alofia le pefu e 'alofia ai le manava ma le fa'afeso'ota'i mata. I le taimi lava e tasi, e tatau ona tausisia tulaga lelei o le ea.
- Aloese mai le fa'afeso'ota'i ma vaila'au fa'ama'i malolosi po'o vaila'au malosi e 'alofia ai fa'alavelave mata'utia