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2 4-Dichloro-5-methylpyrimidine（CAS# 1780-31-0) Ata Fa'aalia
  • 2 4-Dichloro-5-methylpyrimidine（CAS# 1780-31-0) 1

2 4-Dichloro-5-methylpyrimidine（CAS# 1780-31-0)

Meatotino tau vailaau:

Fuafua mole C5H4Cl2N2
Molar Mass 163
Malosi 1.39 g/mL ile 25 °C (malamalama)
Lisi Lisi 26-28 °C (malamalama)
Manu'a 108-109 °C/11 mmHg (malamalama)
Mata'imu >230°F
Solubility Solu i le chloroform, eter, ethyl acetate ma toluene
Ausa Malo 0.079mmHg ile 25°C
Fa'aaliga o le pauta i le pa'u e fa'amama le vai
Lanu Paʻepaʻe pe leai se lanu e toetoe lava paʻepaʻe pe toetoe lava leai se lanu
pKa -2.44±0.29(Vavaloaina)
Tulaga Teuteu Atemosifia le tumau,2-8°C

Fa'amatalaga Oloa

Faailoga o oloa

Tulaga lamatia ma le Saogalemu

Fa'ailoga Mata'utia C – A'a
Tulaga lamatia 34 – Mafua ai mu
Fa'amatalaga Saogalemu S26 – Pe a pa'i i mata, fufulu vave i le tele o vai ma saili fautuaga fa'afoma'i.
S36/37/39 – Fai ofu puipui talafeagai, totigilima ma mata/mata.
S45 – I se fa'alavelave po'o ua e lagona le le lelei, saili vave fautuaga fa'afoma'i (fa'aali le igoa pe a mafai.)
S27 – Aveese loa lavalava uma ua afaina.
UN ID UN 3261 8/PG 2
WGK Siamani 3
TSCA Ioe
HS Code 29335990
Vasega o Tulaga Lamatia 8
Fa'aputu Vaega III

2 4-Dichloro-5-methylpyrimidine（CAS# 1780-31-0) Faamatalaga

Fa'aoga 2, 4-dichloro-5-methylpyrimidine e mafai ona faʻaaogaina i le sauniuniga o le 2-fluoro-5-trifluoromethylpyrimidine. O le 2-fluoro-5-trifluoromethylpyrimidine o se mea taua tele mo le tuʻufaʻatasia o vailaʻau, lea e mafai ona faʻaaogaina e faʻapipiʻi faʻapipiʻi mama dihydrofuran, ma faʻapipiʻi mama dihydrofuran e mafai ona faʻaaogaina e pei o G protein faʻapipiʻi GPR119 modulators, mo togafitiga o le maʻisuka, oona ma fa'ama'i dyslipidemia. E le gata i lea, o le 2-fluoro-5-trifluoromethylpyrimidine e mafai foi ona faʻaaogaina e avea o se vaeluaga i le tuʻufaʻatasia o vailaʻau mo togafitiga o le faʻamaʻi o le Alzheimer ma le schizophrenia.
sauniuniga 5-methyluracil 75g (0.59mol), phosphorus oxychloride 236g, triethylamine hydrochloride 16.5g (0.12mol), faaopoopo i le fagu tali, vevela i le 100 ℃ ~ 110 ℃, Reflux tali 5H, malulu i le 40 ℃, faaopoopo phosphorus 40 ℃ 1.19mol), tali fa'asao vevela 2H. Ina ua maeʻa le tali, na toe maua mai le phosphorus oxychloride e ala i le faʻamama i lalo o le faʻaitiitia o le mamafa, ma le faʻamama i lalo o le faʻaitiitia o le mamafa na faʻaauau pea ona maua le 88g (0.54mol) o le 2, 4-dichloro-5-methylpyrimidine i se fua o le 91.5%.
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